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May 20th, 2015 - Symposium Day 3

Lessons Learned and Pathways Forward

7:45 - 8:30 am Continental Breakfast

8:30 - 10:10 am Session 8: Lessons Learned for Drug Discovery Past, Present, Future Moderator:

Roy Twyman, Janssen Pharmaceuticals Research and Development, US New Therapeutic Targets For Epilepsy - 10 min each:

  • Arne Schousboe, University of Copenhagen - GABAergic Mechanisms
  • Shruthi Iyer*, Creighton University - Antiseizure Effects Of Ketogenic Diet Are Mediated Via Regulation Of Brain PPAR-gamma, A Nutritionally Responsive Transcription Factor
  • Jong Rho, University of Calgary - Bioenergetic Substrates: More Than Just Cellular Fuels
  • Annamaria Vezzani, Mario Negri Institute for Pharmacological Research - miR146aBased Therapy Against Neuroinflammation Has Anti-Ictogenic And Disease-Modifying Effects In Murine Models Of Seizures And Epilepsy
  • Tallie Z. Baram, University of California, Irvine - Epigenetic Targets For Epilepsy / Seizure Prevention
  • James McNamara, Duke University - Targeting TrkB To Prevent Epileptogenesis
  • David Henshall, Royal College of Surgeons in Ireland - MicroRNAs For Antiepileptogenesis

9:40 -10:10 Panel Discussion with Presenters

10:10 - 10:30 Coffee Break

10:30 - 12:00 pm Session 9 – Big Data Moderator: Karen Wilcox, University of Utah

10:30 - 10:45 Tracy Dixon-Salazar, CURE - CURE Updates On Future Directions Based On Epilepsy Genetics: Towards Personalized Medicine

10:45 - 11:00 Richard Normann, University of Utah - Brain Mapping Inititative

11:00 - 11:15 Jeff Loeb, University of Illinois - Systems Biology Approach To Therapeutic Development

11:15 - 11:30 Candace Myers*, University of Washington - EPI4K, Gene Discovery In Epileptic Encephalopathies

11:30 - 11:45 Jeff Anderson, University of Utah - Imaging Neurophysiology Of Distributed Brain Networks

11:45 - 12:00 Panel Wrap-Up - How To Integrate Big Data To Design Big Drugs

12:00 - 12:30 pm Closing Remarks and Pathways Forward Jacqueline French, NYU Langone Medical Center - Moving Preclinical Research To Clinical Treatments Patient Advocate - Remembering Who We Fight For!