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Programm

May 17th, 2015 – Symposium Arrival Day

4:00 - 6:30 pm Symposium Check-In/Registration

6:30 - 9:30 pm Opening Reception - (buffet dinner)

Welcoming Remarks

H. Steve White, ADD Program, University of Utah

Harold H. Wolf, Professor Emeritus, University of Utah

Margo Thurman, Epilepsy Alliance of Utah

Plenary Lecture

Anne T. Berg, Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine - Epidemiological Perspective on the State of Epilepsy Research Needs for the 21st Century

May 18th, 2015 – Symposium Day 1 – Towards Future Innovation through Public/Private Partnerships

7:45 - 8:25 am Continental Breakfast

8:25 am Tom Parks, VP Research, University of Utah - Welcoming Remarks

8:30 Session 1 – Panel: Translational Therapy Discovery: Future

Moderator: H. Steve White, University of Utah

8:30 - 9:00 John Kehne, NINDS - State Of The Anticonvulsant Screening Program Then, Now, And Beyond

9:00 - 9:30 Mike Rogawski, University of California, Davis - Antiepileptic Drugs: Needs For New Treatments And Targets

9:30 - 10:00 Henrik Klitgaard, UCB Pharmaceuticals - Translational Therapies In Epilepsy: Industry Perspective

10:00 - 10:15 Coffee Break

10:15 - 12:00 pm Session 2 – Team Science Approach To Treating The Whole Patient

Moderator: Vicky H. Whittemore, NINDS

Each panelist will provide a 10 min overview that describes their program and how their organization approaches team science and innovation.

• Julie Milder, CURE - Infantile Spasms Initiative

• Chris Schmidt, Pfizer Neuroscience- Pfizer Industry Perspectives On Team Science

• Barbara Slusher, Johns Hopkins University Brain Science Institute - Navigating Private And Academic Drug Discovery Efforts

• Neil Buckholtz, NIA - Accelerating Medicines Partnership Initiative

Panel Discussion - Team Science in the 21st Century – When Does It Work; When Does It Fail? (Julie Milder, Chris Schmidt, Barbara Slusher, and Neil Buckholtz).

12:00 - 1:30 pm Lunch (Junior Investigators to meet with Mentors)

1:30 - 1:50 pm Rajesh Ranganathan, NINDS - NINDS Therapy Development Funding Programs: Lessons Learned And The Road Ahead

2:00pm Session 3 – How Will Genetics Inform Therapy Development?

Moderator: Jeff Noebels, Baylor University

2:00 - 2:20 Heather Mefford, University of Washington - Epi4K Updates And What Has Come About From Team Science

2:20 - 2:40 Jack Parent, University of Michigan - Pluripotent Stem Cell Models Of Epilepsy

2:40 - 3:00 Scott Baraban, UCSF - Zebrafish Models For High-Throughput Drug Discovery

3:00 - 3:30 Break

3:30 - 3:50 David Swinney, Institute for Rare and Neglected Diseases - Discovering New Medicines For Rare Diseases/Mutations

3:50 - 4:30 Panel Discussion - How Do These New Approaches Inform Future Therapy Development? (Graeme Sills, David Swinney, Scott Baraban, Jeff Buchhalter)

5:00 - 7:00 pm Session 4 – Young Investigators Poster Session

Cash Bar, Cocktails and Light Hors d’Oeuvres

Note: Please have all Posters hanging by 8 am Monday, May 18th and available for viewing through symposium close on Wednesday, May 20th

(Dinner on your own)

May 19th, 2015 – Symposium Day 2 – Health Matters in Epilepsy

7:45 - 8:30 am Continental Breakfast

8:30 Session 5 – Comorbid Cognitive And Neuropsychiatric Disorders Of Epilepsy And CNS Disorders With Seizures

Moderator: Amy Brooks-Kayal, University of Colorado

8:35 - 8:55 Kimford Meador, Stanford University - General Overview: Epilepsy And Neuropsychological Comorbidities: Drug Effects On Cognition

8:55 - 9:10 Laura Ewell*, University of California, San Diego - Dentate-Dependent Memory Loss As A Biomarker For Epileptogenesis: Network Level Mechanisms

9:10 - 9:30 Helen Scharfman, NYU Langone Medical Center -Effects Of Epilepsy On Cognition And Cognitive Disorders Associated With Seizures In The Elderly

9:30 - 9:50 Coffee Break

9:50 - 10:05 Angel Lopez*, Baylor College of Medicine - ANK3 Mutations In Bipolar And Epilepsy

10:05 - 10:25 Oleksandr Shcheglovitov, University of Utah - Phelan-McDermid Syndrome And iPSCs

10:25 - 10:45 Andres Kanner, University of Miami - Overview Of The Impact Of Psychiatric Comorbidities On The Course And Treatment Of Seizure Disorders

10:45 - 11:30 Panel Discussion Wrap-Up - How Does Knowledge About Shared Pathologies And Comorbidities Drive Therapy Development? (Andres Kanner, Amy Brooks-Kayal, Helen Scharfman, Misty D. Smith, Peter West)

11:30 - 1:30 Lunch (Junior Investigators to meet with Mentors)

1:30 Session 6 – Clinical Considerations, Biomarkers, and Pathways Forward

Moderator: Terence O’Brien, University of Melbourne

1:30–1:50 Manisha Patel, University of Colorado - Metabolomics of Epilepsy

1:50–2:10 Alicia Goldman, Baylor University - SUDEP: Pathways, Biomarkers, And Opportunities For Therapeutic Interventions

2:10–2:25 Lisa Coles*, University of Minnesota - Academic Drug Discovery And Development Teams: The Power Of Pharmacokinetic And Pharmacodynamic Modeling And Simulation

2:25–2:45 William Theodore, NINDS - Imaging Neuroinflammation And Other Biomarkers In The Brain Of Patients With Epilepsy

2:45–3:05 Asla Pitkänen, University of Eastern Finland - Gender Issues In Antiepileptogenic Therapy Development

3:05–3:30 Panel Discussion - Biomarkers For Therapy Discovery (Manisha Patel, Alicia Goldman, William Theodore)

3:30–3:45 Break

3:45 pm Session 7 – Data Blitz - Emerging Models

Moderator: Roger Porter

3:45 – 4:00 Wolfgang Löscher, University of Veterinary Medicine, Hannover - State Of Animal Models – Redux

4:00–4:15 Raimondo D’Ambrosio, University of Washington - Updates On The FPI-Model As Antiepileptogenic Screen

4:15–4:30 Aristea Galanopoulou, Albert Einstein College of Medicine - Towards The Development Of Pediatric Epilepsy Models

4:30–4:45 Melissa Barker-Haliski, University of Utah -The TMEV Model Of Inflammation-Induced Seizures For Screening Of Investigational Drugs

4:45–5:00 Andrew Tidball*, University of Michigan -Modeling SCN8A Mutant Epilepsy In Patient-Derived Cortical And Autonomic Neurons

5:00–5:15 Corinne Roucard, SynapCell SAS - The MTLE Mouse For Drug Screening

5:15–5:30 Robert Sloviter, Morehouse School of Medicine - The Perforant Path Stimulation Model; Unilateral Hippocampal-Onset Epilepsy With Hippocampal Sclerosis In Rats

5:30–5:45 Kyle Thomson, University of Utah - A Clinically Relevant Model For Screening Anticonvulsants In Chronically Epileptic Rats

5:45–6:00 Roger Porter and Wolfgang Löscher - Wrap-Up – What Do Future Models Need?

(Dinner on your own)

May 20th, 2015 – Symposium Day 3: Lessons Learned and Pathways Forward

7:45–8:30 am Continental Breakfast

8:30–10:10 am Session 8: Lessons Learned for Drug Discovery Past, Present, Future

Moderator: Roy Twyman, Janssen Pharmaceuticals Research and Development, US

New Therapeutic Targets For Epilepsy – 10 min each:

• Arne Schousboe, University of Copenhagen - GABAergic Mechanisms

• Shruthi Iyer*, Creighton University - Antiseizure Effects Of Ketogenic Diet Are Mediated Via Regulation Of Brain PPAR-gamma, A Nutritionally Responsive Transcription Factor

• Jong Rho, University of Calgary - Bioenergetic Substrates: More Than Just Cellular Fuels

• Annamaria Vezzani, Mario Negri Institute for Pharmacological Research - miR146a-Based Therapy Against Neuroinflammation Has Anti-Ictogenic And Disease-Modifying Effects In Murine Models Of Seizures And Epilepsy

• Tallie Z. Baram, University of California, Irvine - Epigenetic Targets For Epilepsy / Seizure Prevention

• James McNamara, Duke University - Targeting TrkB To Prevent Epileptogenesis

• David Henshall, Royal College of Surgeons in Ireland - MicroRNAs For Antiepileptogenesis

9:40-10:10 Panel Discussion with Presenters

10:10–10:30 Coffee Break

10:30-12:00pm Session 9 – Big Data

Moderator: Karen Wilcox, University of Utah

10:30–10:45 Tracy Dixon-Salazar, CURE - CURE Updates On Future Directions Based On Epilepsy Genetics: Towards Personalized Medicine

10:45–11:00 Richard Normann, University of Utah - Brain Mapping Inititative

11:00–11:15 Jeff Loeb, University of Illinois - Systems Biology Approach To Therapeutic Development

11:15–11:30 Candace Myers*, University of Washington - EPI4K, Gene Discovery In Epileptic Encephalopathies

11:30–11:45 Jeff Anderson, University of Utah - Imaging Neurophysiology Of Distributed Brain Networks

11:45–12:00 Panel Wrap-Up - How To Integrate Big Data To Design Big Drugs

12:00–12:30 pm Closing Remarks and Pathways Forward

Jacqueline French, NYU Langone Medical Center - Moving Preclinical Research To Clinical Treatments

Patient Advocate - Remembering Who We Fight For!